University of Arizona College of Medicine - Phoenix

Conditions

• ALK Gene Rearrangement
• ALK Gene Translocation
• ALK Positive
• Stage IB Non-Small Cell Lung Carcinoma AJCC v7
• Stage II Non-Small Cell Lung Cancer AJCC v7
• Stage IIA Non-Small Cell Lung Carcinoma AJCC v7
• Stage IIB Non-Small Cell Lung Carcinoma AJCC v7
• Stage IIIA Non-Small Cell Lung Cancer AJCC v7

Eligibility

Eligible Ages

Over 18 Years

Eligible Genders

All

Accepts Healthy Volunteers

No

Criteria

Inclusion Criteria:

- Patients must have undergone complete surgical resection of their stage IB (>= 4
cm), II, or non-squamous IIIA NSCLC per American Joint Committee on Cancer (AJCC)
7th edition and have had negative margins; N3 disease is not allowed

- Baseline chest computed tomography (CT) with or without contrast must be performed
within 6 months (180 days) prior to randomization to ensure no evidence of disease;
if clinically indicated additional imaging studies must be performed to rule out
metastatic disease

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

- Patients must be registered to the ALCHEMIST-SCREEN (ALLIANCE A151216) trial prior
to randomization

- Positive for translocation or inversion events involving the ALK gene locus (e.g.
resulting in echinoderm microtubule associated protein like 4 [EML4]-ALK fusion) as
determined by the Vysis Break Point fluorescence in situ hybridization (FISH) assay
and defined by an increase in the distance between 5? and 3? ALK probes or the loss
of the 5? probe; this must have been performed:

- By a local Clinical Laboratory Improvement Amendments (CLIA) certified
laboratory: report must indicate the results as well as the CLIA number of the
laboratory which performed the assay; tissue must be available for submission
for central, retrospective confirmation of the ALK fusion status via
ALCHEMIST-SCREEN (ALLIANCE A151216) OR

- Patient registered to and the ALK fusion status performed centrally on the
ALCHEMIST-SCREEN (ALLIANCE A151216)

- Women must not be pregnant or breast-feeding

- All females of childbearing potential must have a blood or urine pregnancy test
within 72 hours prior to randomization to rule out pregnancy; a female of
childbearing potential is any woman, regardless of sexual orientation or whether
they have undergone tubal ligation, who meets the following criteria: 1) has not
undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally
postmenopausal for at least 24 consecutive months (i.e., has had menses at any time
in the preceding 24 consecutive months)

- Women of childbearing potential and sexually active males must be strongly advised
to practice abstinence or use an accepted and effective method of contraception

- Patients must NOT have uncontrolled intercurrent illness including, but not limited
to, serious ongoing or active infection, symptomatic congestive heart failure,
unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric
illness/social situations that would limit compliance with study requirements

- No known interstitial fibrosis or interstitial lung disease

- No prior treatment with crizotinib or another ALK inhibitor

- No ongoing cardiac dysrhythmias of grade >= 2 National Cancer Institute (NCI) Common
Terminology Criteria for Adverse Events (CTCAE) version 4.0, uncontrolled atrial
fibrillation (any grade), or corrected QT (QTc) interval > 470 msec

- No use of medications, herbals, or foods that are known potent cytochrome P450,
subfamily 3A, polypeptide 4 (CYP3A4) inhibitors or inducers, included but not
limited to those outlined

- Patients must be adequately recovered from surgery at the time of randomization

- The minimum time requirement between date of surgery and randomization must be at
least 4 weeks (28 days)

- The maximum time requirement between surgery and randomization must be:

- 3 months (90 days) if no adjuvant chemotherapy was administered

- 8 months (240 days) if adjuvant chemotherapy was administered

- 10 months (300 days) if adjuvant chemotherapy and radiation therapy were
administered

- Patients must have completed any prior adjuvant chemotherapy or radiation therapy 2
or more weeks (6 or more weeks for mitomycin and nitrosoureas) prior to
randomization and be adequately recovered at the time of randomization

- NOTE: Patients taking low dose methotrexate for non-malignant conditions and
other cytotoxic agents for non-malignant conditions are allowed to continue
treatment while on study

- NOTE: Neo-adjuvant chemotherapy or radiation therapy for the resected lung
cancer is not permitted

- Serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) =<
2.5 x upper limit of normal (ULN)

- Total serum bilirubin =< 1.5 x ULN

- Absolute neutrophil count (ANC) >= 1500/mm^3

- Platelets >= 30,000/mm^3

- Hemoglobin >= 8.0 g/dL

- Serum creatinine =< 2 x ULN

- Prior to randomization patients with any non-hematologic toxicity from surgery,
chemotherapy, or radiation must have recovered to grade =< 1 with the exception of
alopecia and the criteria outlined

- Patients must not have any history of locally advanced or metastatic cancer
requiring systemic therapy within 5 years from randomization, with the exception of
in-situ carcinomas and non-melanoma skin cancer; patients must have no previous
primary lung cancer diagnosed concurrently or within the past 2 years

- Patients may not be receiving any other investigational agents while on study

Recruiting Locations

Study Contact

Detailed Description

PRIMARY OBJECTIVES: I. To evaluate whether adjuvant therapy with crizotinib will result in improved overall survival (OS) for patients with stage IB >= 4 cm, II and IIIA, ALK-positive non-small cell lung cancer (NSCLC) following surgical resection. SECONDARY OBJECTIVES: I. To evaluate and compare disease-free survival (DFS) associated with crizotinib. II. To evaluate the safety profile of crizotinib when given in the adjuvant therapy setting. III. To collect tumor tissue and blood specimens for future research. OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM A: Patients receive crizotinib orally (PO) twice daily (BID) on days 1-21. Treatment repeats every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. ARM B: Patients undergo observation. After completion of study treatment, patients are followed up every 6 months if < 4 or 5 years from study entry, and every 12 months if 5-10 or 6-10 years from study entry.